NAIP and HPCA

Data Source:
HPRD (in vitro, two hybrid)

		NAIP	HPCA
Description		NLR family apoptosis inhibitory protein	hippocalcin
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GO Annotations	Cellular Component	Cytoplasm Basolateral Plasma Membrane IPAF Inflammasome Complex	Cytoplasm Cytosol Extrinsic Component Of Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Glutamatergic Synapse
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding
	Biological Process	Apoptotic Process Inflammatory Response Nervous System Development Detection Of Bacterium Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Pyroptosis	Brain Development Calcium-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Activation Of Phospholipase D Activity Positive Regulation Of Adenylate Cyclase Activity Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Cellular Response To Monosodium Glutamate Response To Aroclor 1254
Pathways
Drugs
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		3 interacting genes: CASP9 HPCA MAP3K7	16 interacting genes: C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		4671	3208
HPRD ID		09049	00811
Ensembl ID		ENSG00000249437	ENSG00000121905
Uniprot IDs		Q13075	P84074
PDB IDs		2VM5	5G4P 5G58 5M6C
Enriched GO Terms of Interacting Partners?
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