MYH11 and MAPKAPK5

Data Source:
HPRD (in vitro)

		MYH11	MAPKAPK5
Description		myosin heavy chain 11	MAPK activated protein kinase 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Myosin Complex Myosin Filament Melanosome Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Motor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding	P53 Binding Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity MAP Kinase Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Muscle Contraction Smooth Muscle Contraction Skeletal Muscle Myosin Thick Filament Assembly Elastic Fiber Assembly Cardiac Muscle Fiber Development	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Negative Regulation Of TOR Signaling Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Protein Autophosphorylation Positive Regulation Of Telomerase Activity Stress-induced Premature Senescence Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Telomere Capping
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation
Drugs		Tetrafluoroaluminate Ion	Fostamatinib
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Cognitive function ( 25644384) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Resting heart rate ( 29769521 27798624) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789) Skin aging measurement ( 31522824) Waist-hip ratio ( 23966867)	Adult body size ( 32376654) Body mass index ( 26426971) Coffee consumption ( 29367735) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mean spheric corpuscular volume ( 32888494) Psoriasis ( 28537254)
Interacting Genes		4 interacting genes: APC DAXX GRB2 MAPKAPK5	29 interacting genes: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PARK7 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		4629	8550
HPRD ID		01174	09467
Ensembl ID		ENSG00000133392	ENSG00000089022
Uniprot IDs		A0A024QZJ4 A0A024QZJ6 P35749	Q8IW41
PDB IDs
Enriched GO Terms of Interacting Partners?
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