MTAP and MYLIP

Data Source:
HPRD (in vitro, two hybrid)

		MTAP	MYLIP
Description		methylthioadenosine phosphorylase	myosin regulatory light chain interacting protein
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Response To Testosterone Interleukin-12-mediated Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways		Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS		Adverse response to drug ( 30420678) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous malignant melanoma ( 32341527) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Mean spheric corpuscular volume ( 32888494) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 32341527 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)	Apolipoprotein B levels ( 32203549) Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)
Interacting Genes		7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB	41 interacting genes: ADAMTSL4 AR ARID5A CNPY2 CRK DAPP1 DDIT4L EFHC2 EXOSC5 FAM217B GMCL1 HOOK2 INO80B KANK4 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B NHLRC4 NOXA1 NR1D2 PAX9 RASSF5 SCNM1 SDCBP SRPK2 TCEANC TSC1 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR ZBTB16 ZBTB18 ZBTB42 ZNF417 ZNF438
Entrez ID		4507	29116
HPRD ID		01134	17621
Ensembl ID		ENSG00000099810	ENSG00000007944
Uniprot IDs		A0A384ME80 Q13126	Q5TIA5 Q8WY64
PDB IDs		1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3	2YHN 2YHO 6QLY 6QLZ
Enriched GO Terms of Interacting Partners?
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