MSN and PRKCQ

Data Source:
HPRD (in vitro)

		MSN	PRKCQ
Description		moesin	protein kinase C theta
Image
GO Annotations	Cellular Component	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle	Immunological Synapse Cytosol Plasma Membrane Aggresome Centriolar Satellite
	Molecular Function	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Viral Process Gland Morphogenesis Membrane To Membrane Docking Interleukin-12-mediated Signaling Pathway T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Cellular Response To Testosterone Stimulus Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Membrane Protein Ectodomain Proteolysis Inflammatory Response Axon Guidance Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Insulin Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Telomerase Activity Cell Chemotaxis Negative Regulation Of T Cell Apoptotic Process Regulation Of Platelet Aggregation Positive Regulation Of Telomere Capping Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 2 Cell Activation
Pathways		Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Apoptotic cleavage of cellular proteins Effects of PIP2 hydrolysis Downstream TCR signaling Inactivation, recovery and regulation of the phototransduction cascade FCERI mediated NF-kB activation FCERI mediated NF-kB activation Netrin-1 signaling G alpha (z) signalling events RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RAS processing
Drugs			Tamoxifen Staurosporine Phosphonothreonine Dexfosfoserine Fostamatinib
Diseases			Type I diabetes mellitus
GWAS		Male-pattern baldness ( 28196072)	Asthma ( 31959851 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 31036433 30929738) Autoimmune traits (pleiotropy) ( 30572963) Body mass index in asthmatics ( 23517042) Celiac disease ( 22057235 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Factor VII activity ( 30642921) Immune response to smallpox vaccine (IL-6) ( 22542470) Medication use (thyroid preparations) ( 31015401) Rheumatoid arthritis ( 30423114 18794853 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 24532676) Type 1 diabetes ( 19430480 18978792)
Interacting Genes		31 interacting genes: BCAP31 CD44 CD46 CD93 CDK11B ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11	27 interacting genes: AKT1 BTK CARD11 CASP3 CBL CHUK CISH FYN GLRX3 GRM5 HABP4 ICAM3 IKBKB IKBKG IRS1 LCK LYN MARK3 MSN RASGRP3 SELL STK39 TAL1 VAV1 WIPF1 YWHAG YWHAQ
Entrez ID		4478	5588
HPRD ID		02399	02710
Ensembl ID		ENSG00000147065	ENSG00000065675
Uniprot IDs		P26038 V9HWC0	Q04759
PDB IDs		1E5W 1EF1 1SGH 6TXQ 6TXS	1XJD 2ENJ 2ENN 2ENZ 2JED 4Q9Z 4RA5 5F9E
Enriched GO Terms of Interacting Partners?
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