ASNS and WDR27

Data Source:
BioGRID (two hybrid)

		ASNS	WDR27
Description		asparagine synthetase (glutamine-hydrolyzing)	WD repeat domain 27
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleoplasm
	Molecular Function	Asparagine Synthase (glutamine-hydrolyzing) Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding
	Biological Process	Liver Development Asparagine Biosynthetic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Response To Light Stimulus Response To Mechanical Stimulus Response To Toxic Substance Response To Methotrexate Response To Follicle-stimulating Hormone Cellular Response To Hormone Stimulus PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Mitotic Cell Cycle L-asparagine Biosynthetic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Aspartate and asparagine metabolism Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Aspartic acid Glutamic acid ATP Asparagine
Diseases
GWAS		Regular attendance at a religious group ( 29970889) Tuberculosis ( 30713548)	Carotid intima media thickness x smoking interaction ( 32117412) Eye morphology ( 29921221) Hallux valgus ( 32131869) Insomnia ( 27992416) Insomnia complaints ( 28604731) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Type 1 diabetes ( 21980299)
Interacting Genes		5 interacting genes: ATXN1 STRN4 SUMO2 TRIM69 WDR27	1 interacting genes: ASNS
Entrez ID		440	253769
HPRD ID		00153	11352
Ensembl ID		ENSG00000070669	ENSG00000184465
Uniprot IDs		P08243	A2RRH5
PDB IDs		6GQ3
Enriched GO Terms of Interacting Partners?
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