MPP3 and IDUA

Data Source:
HPRD (two hybrid)

		MPP3	IDUA
Description		membrane palmitoylated protein 3	alpha-L-iduronidase
Image		No pdb structure
GO Annotations	Cellular Component		Coated Vesicle Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding	L-iduronidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Signaling Receptor Binding
	Biological Process		Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Heparin Catabolic Process
Pathways			HS-GAG degradation CS/DS degradation MPS I - Hurler syndrome
Drugs
Diseases			Mucopolysaccharidosis type I (MPS1); Hurler-Scheie syndrome (MPS1HS); Hurler syndrome (MPS1H); Scheie syndrome (MPS1S)
GWAS		HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068)	Blood protein levels ( 30072576 29875488) Heel bone mineral density ( 30598549) Limited cutaneous systemic scleroderma ( 29293537) Lumbar spine bone mineral density ( 22504420) Mean reticulocyte volume ( 32888494) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269)
Interacting Genes		39 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A LIN7B LIN7C MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	1 interacting genes: MPP3
Entrez ID		4356	3425
HPRD ID		03069	02016
Ensembl ID		ENSG00000161647	ENSG00000127415
Uniprot IDs		D3DX46 Q13368	P35475
PDB IDs			1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4 4OBR 4OBS 6I6R 6I6X
Enriched GO Terms of Interacting Partners?
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