MPP1 and ACER2

Data Source:
BioGRID (two hybrid)

		MPP1	ACER2
Description		membrane palmitoylated protein 1	alkaline ceramidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cortical Cytoskeleton Stereocilium Centriolar Satellite	Golgi Membrane Golgi Apparatus Integral Component Of Golgi Membrane
	Molecular Function	Guanylate Kinase Activity Protein Binding	N-acylsphingosine Amidohydrolase Activity Metal Ion Binding Dihydroceramidase Activity Ceramidase Activity
	Biological Process	Signal Transduction GMP Metabolic Process GDP Metabolic Process Regulation Of Neutrophil Chemotaxis	Negative Regulation Of Cell-matrix Adhesion Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Cell Death Sphingolipid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Retinoic Acid Negative Regulation Of Cell Adhesion Mediated By Integrin Cellular Response To Drug Regulation Of Apoptotic Process Sphingosine Biosynthetic Process Ceramide Catabolic Process Negative Regulation Of Protein Glycosylation In Golgi
Pathways			Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Hematology traits ( 23263863) Mean corpuscular volume ( 23263863) Red blood cell traits ( 23446634)
Interacting Genes		43 interacting genes: ABCC4 ACER1 ACER2 AGPAT3 AMOTL2 AP2M1 APH1A ATP5F1C ATRAID BHLHB9 DERL2 DGAT2L6 DNPEP ERBIN GADD45A GSK3B GYPC HNRNPD INCA1 KLHL12 MAP3K20 MEOX2 NR1H2 OPTN PAQR8 PRIMPOL RPRM RPS6KA1 RPS6KA6 SGSM2 SLC35E1 SMN1 SRSF10 STK3 STUB1 SYNGR3 TK1 TMEM239 TRIM55 TRIM63 USP21 UXT ZNF639	1 interacting genes: MPP1
Entrez ID		4354	340485
HPRD ID		02370	16512
Ensembl ID		ENSG00000130830	ENSG00000177076
Uniprot IDs		B4E325 Q00013	B3KVV5 Q5QJU3
PDB IDs		2EJY 2EV8 3NEY
Enriched GO Terms of Interacting Partners?
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