MMP8 and UMOD

Data Source:
HPRD (in vitro)

		MMP8	UMOD
Description		matrix metallopeptidase 8	uromodulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Specific Granule Lumen Collagen-containing Extracellular Matrix Tertiary Granule Lumen	Spindle Pole Extracellular Space Endoplasmic Reticulum Golgi Lumen Cilium Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Ciliary Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding IgG Binding
	Biological Process	Proteolysis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Endodermal Cell Differentiation Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JNK Cascade Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Activation	Allantoin Metabolic Process Organ Or Tissue Specific Immune Response Renal Water Homeostasis Glomerular Filtration Lipid Metabolic Process Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Autophagy Inflammatory Response Cellular Defense Response Endoplasmic Reticulum Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Excretion Negative Regulation Of Cell Population Proliferation RNA Splicing Response To Water Deprivation Peptidyl-threonine Phosphorylation Urate Catabolic Process Ubiquitin-dependent ERAD Pathway Cellular Phosphate Ion Homeostasis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Unfolded Protein Regulation Of Urine Volume Response To Drug Citric Acid Secretion Defense Response To Gram-negative Bacterium Regulation Of Protein Transport Chaperone-mediated Protein Folding Renal Sodium Ion Absorption Collecting Duct Development Juxtaglomerular Apparatus Development Metanephric Ascending Thin Limb Development Metanephric Distal Convoluted Tubule Development Metanephric Thick Ascending Limb Development Protein Localization To Vacuole Apoptotic Signaling Pathway Creatinine Homeostasis Connective Tissue Replacement Neutrophil Migration
Pathways		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Neutrophil degranulation	Asparagine N-linked glycosylation
Drugs		Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 5-[4-(2-Hydroxyethyl)-1-piperidinyl]-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione Glycinamide Batimastat N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid (1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
GWAS		Blood protein levels ( 30072576) Epilepsy ( 25087078) Prostate cancer ( 23535732)	Chronic kidney disease ( 29124443 26831199 20383146) Chronic kidney disease and serum creatinine levels ( 20686651) Chronic kidney disease x type 2 diabetes interaction ( 32541925) Creatinine levels ( 29124443) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31015462 29124443 30604766) Femoral neck bone geometry ( 22087292) Glomerular filtration rate ( 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate (cystatin C) ( 28452372) Glomerular filtration rate in diabetes ( 29703844) Glomerular filtration rate in diabetics (creatinine) ( 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Glomerular filtration rate in type 2 diabetes ( 29703844) Hypertension ( 27618447 21082022) Hyperuricemia ( 29124443) Kidney function decline traits ( 25493955) Kidney stones ( 31729369) Medication use (calcium channel blockers) ( 31015401) Renal function and chronic kidney disease ( 19430482) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 29124443) Urate levels ( 31578528) Urinary uromodulin levels ( 24578125)
Interacting Genes		7 interacting genes: ACAN BCAN CCL2 FBXO7 TFPI TIMP2 UMOD	3 interacting genes: LINC02582 LTA MMP8
Entrez ID		4317	7369
HPRD ID		00385	11771
Ensembl ID		ENSG00000118113	ENSG00000169344
Uniprot IDs		B4E0I2 P22894	P07911
PDB IDs		1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4 4QKZ 5H8X	4WRN 6TQK 6TQL 6ZS5 6ZYA
Enriched GO Terms of Interacting Partners?
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