AFDN and RPS6KA2

Data Source:
BioGRID (proximity labelling technology)

		AFDN	RPS6KA2
Description		afadin, adherens junction formation factor	ribosomal protein S6 kinase A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Adherens Junction Organization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Signal Transduction Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) Dental caries ( 23259602) Inflammatory bowel disease ( 27569725 23128233) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		37 interacting genes: BCR CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53
Entrez ID		4301	6196
HPRD ID		01164	03403
Ensembl ID		ENSG00000130396	ENSG00000071242
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	B7Z3B5 Q15349 X5D337
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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