RAB8A and MALT1

Data Source:
BioGRID (proximity labelling technology)

		RAB8A	MALT1
Description		RAB8A, member RAS oncogene family	MALT1 paracaspase
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GO Annotations	Cellular Component	Golgi Membrane Endosome Centrosome Centriole Cytosol Plasma Membrane Cilium Synaptic Vesicle Postsynaptic Density Trans-Golgi Network Transport Vesicle Midbody Phagocytic Vesicle Membrane Trans-Golgi Network Membrane Neuronal Cell Body Dendritic Spine Phagocytic Vesicle Recycling Endosome Membrane Extracellular Exosome Non-motile Cilium Glutamatergic Synapse	Fibrillar Center Polkadots Nucleus Cytoplasm Cytosol CBM Complex Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding	Protease Binding Cysteine-type Endopeptidase Activity Ubiquitin-protein Transferase Activity Protein Binding Peptidase Activity Kinase Activator Activity Identical Protein Binding Protein Self-association
	Biological Process	Vesicle Docking Involved In Exocytosis Autophagy Axonogenesis Protein Secretion Regulation Of Autophagy Regulation Of Exocytosis Cellular Response To Insulin Stimulus Post-translational Protein Modification Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	B-1 B Cell Differentiation Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Proteolysis Defense Response Activation Of NF-kappaB-inducing Kinase Activity Response To Fungus Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway T Cell Proliferation B Cell Activation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Nuclear Export Positive Regulation Of T-helper 17 Cell Differentiation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling CLEC7A/inflammasome pathway
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494) Red cell distribution width ( 32888494)	Metabolite levels ( 23823483) Multiple sclerosis ( 31604244 21833088)
Interacting Genes		23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC	16 interacting genes: BCL10 CARM1 FEM1A FEM1C KDM1A PRMT6 RBCK1 RELB SQSTM1 SUV39H1 TRAF2 TRAF6 UBC UBE2N UBE2V2 USP2
Entrez ID		4218	10892
HPRD ID		01296	06892
Ensembl ID		ENSG00000167461	ENSG00000172175
Uniprot IDs		A0A024R7I3 P61006	A8K5S1 Q9UDY8
PDB IDs		3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6ZSI 6ZSJ	2G7R 3BFO 3K0W 3UO8 3UOA 3V4O 3V55 4I1P 4I1R 6F7I 6GK2 6H4A 6YN8 6YN9
Enriched GO Terms of Interacting Partners?
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