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MALT1 and CARM1
Data Source:
BioGRID
(two hybrid)
MALT1
CARM1
Description
MALT1 paracaspase
coactivator associated arginine methyltransferase 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Polkadots
Nucleus
Cytoplasm
Cytosol
CBM Complex
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protease Binding
Cysteine-type Endopeptidase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Peptidase Activity
Kinase Activator Activity
Identical Protein Binding
Protein Self-association
Transcription Regulatory Region Sequence-specific DNA Binding
Transcription Coactivator Activity
Protein Binding
Beta-catenin Binding
Protein Methyltransferase Activity
Histone-arginine N-methyltransferase Activity
Protein-arginine N-methyltransferase Activity
Nuclear Receptor Coactivator Activity
Protein-arginine Omega-N Asymmetric Methyltransferase Activity
Histone Methyltransferase Activity (H3-R17 Specific)
Histone Methyltransferase Activity
Lysine-acetylated Histone Binding
Biological Process
B-1 B Cell Differentiation
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Proteolysis
Defense Response
Activation Of NF-kappaB-inducing Kinase Activity
Response To Fungus
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-2 Production
Fc-epsilon Receptor Signaling Pathway
T Cell Proliferation
B Cell Activation
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nuclear Export
Positive Regulation Of T-helper 17 Cell Differentiation
Regulation Of Transcription, DNA-templated
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Aging
Positive Regulation Of Cell Population Proliferation
Viral Process
Histone Methylation
Regulation Of Lipid Metabolic Process
Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Histone H3-R2 Methylation
Histone H3-R17 Methylation
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Response To CAMP
Regulation Of MRNA Binding
Negative Regulation Of Dendrite Development
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by PPARalpha
Circadian Clock
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Estrogen-dependent gene expression
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
31604244
21833088
)
C-reactive protein levels or LDL-cholesterol levels (pleiotropy) (
27286809
)
C-reactive protein levels or total cholesterol levels (pleiotropy) (
27286809
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Interacting Genes
16 interacting genes:
BCL10
CARM1
FEM1A
FEM1C
KDM1A
PRMT6
RBCK1
RELB
SQSTM1
SUV39H1
TRAF2
TRAF6
UBC
UBE2N
UBE2V2
USP2
33 interacting genes:
AXIN1
CREBBP
CTNNB1
DAXX
DNAJA3
DZIP3
ELAVL1
EP300
FLII
FOS
GRIP1
H3-3A
H3-3B
H3C1
MALT1
MEF2D
MYOD1
MYOG
NCOA1
NCOA2
NUDT21
PABPC1
PABPN1
PRMT8
PYGO1
QKI
RABGAP1
RELA
SMARCA4
SPAG8
SRCAP
TP53
UBE2I
Entrez ID
10892
10498
HPRD ID
06892
09158
Ensembl ID
ENSG00000172175
ENSG00000142453
Uniprot IDs
A8K5S1
Q9UDY8
Q86X55
PDB IDs
2G7R
3BFO
3K0W
3UO8
3UOA
3V4O
3V55
4I1P
4I1R
6F7I
6GK2
6H4A
6YN8
6YN9
2Y1W
2Y1X
4IKP
5DWQ
5DX0
5DX1
5DX8
5DXA
5DXJ
5U4X
6ARJ
6ARV
6D2L
6DVR
6IZQ
6S70
6S71
6S74
6S77
6S79
6S7A
6S7B
6S7C
Enriched GO Terms of Interacting Partners
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