MAP3K4 and EPHB4

Data Source:
BioGRID (biochemical)

		MAP3K4	EPHB4
Description		mitogen-activated protein kinase kinase kinase 4	EPH receptor B4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Perinuclear Region Of Cytoplasm	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex Extracellular Exosome
	Molecular Function	MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Response To UV-C Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping	Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Heart Morphogenesis Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib	Dasatinib N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3,4,5- TRIMETHOXYPHENYL)PYRIMIDINE-2,4-DIAMINE N'-(3-CHLORO-4-METHOXY-PHENYL)-N-(3,4,5-TRIMETHOXYPHENYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide N'-(5-chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine N-[3-[[4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL]AMINO]PHENYL]METHANESULFONAMIDE N'-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-N-(3-MORPHOLIN-4-YLPHENYL)PYRIMIDINE-2,4-DIAMINE 3-({4-[(5-CHLORO-1,3-BENZODIOXOL-4-YL)AMINO]PYRIMIDIN-2-YL}AMINO)BENZAMIDE Tesevatinib Fostamatinib
Diseases
GWAS		Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)	Bipolar disorder ( 31043756) Blond vs. brown/black hair color ( 30531825) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Platelet distribution width ( 32888494) Resting heart rate ( 27798624)
Interacting Genes		26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ	5 interacting genes: APP EFNB2 FBXO7 GRIN1 SDC3
Entrez ID		4216	2050
HPRD ID		03886	02481
Ensembl ID		ENSG00000085511	ENSG00000196411
Uniprot IDs		Q9P1M2 Q9Y6R4	P54760 Q541P7 Q96L35
PDB IDs			2BBA 2E7H 2HLE 2QKQ 2VWU 2VWV 2VWW 2VWX 2VWY 2VWZ 2VX0 2VX1 2X9F 2XVD 2YN8 3ZEW 4AW5 4BB4 6FNI 6FNJ 6FNK 6FNL 6FNM
Enriched GO Terms of Interacting Partners?
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