ME1 and AP1B1

Data Source:
HPRD (two hybrid)

		ME1	AP1B1
Description		malic enzyme 1	adaptor related protein complex 1 subunit beta 1
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GO Annotations	Cellular Component	Mitochondrion Cytosol	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NAD+) Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Oxaloacetate Decarboxylase Activity Electron Transfer Activity Manganese Ion Binding Identical Protein Binding ADP Binding NADP Binding NAD Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Carbohydrate Metabolic Process Pyruvate Metabolic Process Malate Metabolic Process Nucleotide Biosynthetic Process Response To Hormone Response To Carbohydrate Regulation Of Lipid Metabolic Process Electron Transport Chain Regulation Of NADP Metabolic Process	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus
Pathways		PPARA activates gene expression Pyruvate metabolism	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs		NADH Nicotinamide adenine dinucleotide phosphate
Diseases
GWAS		Birth weight ( 31043758) Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome ( 31991592)	Carotid atherosclerosis in HIV infection ( 20009918) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes			43 interacting genes: AGR3 AP1G1 AP1G2 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CLTC CREBBP CRYBB1 FARS2 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PIP5K1C POM121 PRKDC PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1 U2AF1L5
Entrez ID		4199	162
HPRD ID		01102	02541
Ensembl ID		ENSG00000065833	ENSG00000100280
Uniprot IDs		P48163	Q10567
PDB IDs		2AW5 3WJA	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF
Enriched GO Terms of Interacting Partners?
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