MC3R and ASIP

Data Source:
HPRD (in vitro)

		MC3R	ASIP
Description		melanocortin 3 receptor	agouti signaling protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Regulation Of Heart Rate G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Regulation Of Metabolic Process Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Sodium Ion Homeostasis Regulation Of Feeding Behavior	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Positive Regulation Of Melanin Biosynthetic Process Genetic Imprinting
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Bremelanotide
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 25963972 18488028) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		3 interacting genes: AGRP ASIP POMC	6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4159	434
HPRD ID		01115	02562
Ensembl ID		ENSG00000124089	ENSG00000101440
Uniprot IDs		P41968	P42127
PDB IDs			1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?
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