MC2R and ASIP

Data Source:
HPRD (in vitro)

		MC2R	ASIP
Description		melanocortin 2 receptor	agouti signaling protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Placenta Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Regulation Of Metabolic Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Positive Regulation Of Melanin Biosynthetic Process Genetic Imprinting
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tetracosactide Corticotropin Seractide acetate Bremelanotide
Diseases		Adrenal carcinoma
GWAS		Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Negative urgency ( 30718321) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)	Blood protein levels ( 30072576 29875488) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 25963972 18488028) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		4 interacting genes: ASIP MRAP MRAP2 POMC	6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		4158	434
HPRD ID		06304	02562
Ensembl ID		ENSG00000185231	ENSG00000101440
Uniprot IDs		Q01718	P42127
PDB IDs			1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?
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