MATK and NFIX

Data Source:
BioGRID (proximity labelling technology)

		MATK	NFIX
Description		megakaryocyte-associated tyrosine kinase	nuclear factor I X
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Membrane	Chromatin Nucleus
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Downregulation of ERBB2 signaling	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs		Fostamatinib
Diseases
GWAS		Obesity-related traits ( 23251661)	Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Intelligence (MTAG) ( 29326435) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	8 interacting genes: JMJD6 MLH1 NFIB PIR QRICH1 RFX1 SKI ZNF614
Entrez ID		4145	4784
HPRD ID		02496	01234
Ensembl ID		ENSG00000007264	ENSG00000008441
Uniprot IDs		F1T0G6 P42679	B4DHW2 Q14938
PDB IDs		1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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