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SMAD4 and GATA2
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, two hybrid)
SMAD4
GATA2
Description
SMAD family member 4
GATA binding protein 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
SMAD Protein Complex
Heteromeric SMAD Protein Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Metal Ion Binding
I-SMAD Binding
R-SMAD Binding
Transcription Regulator Activator Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Outflow Tract Septum Morphogenesis
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Brainstem Development
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
SMAD Protein Complex Assembly
Spermatogenesis
Single Fertilization
Axon Guidance
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Anatomical Structure Morphogenesis
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Neural Crest Cell Differentiation
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Differentiation
Negative Regulation Of Cell Growth
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Luteinizing Hormone Secretion
Somatic Stem Cell Population Maintenance
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Embryonic Digit Morphogenesis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Binding
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Negative Regulation Of Cell Death
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Response To Transforming Growth Factor Beta
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Histone H3-K9 Acetylation
Urogenital System Development
Cell Fate Determination
Neuron Migration
Embryonic Placenta Development
Regulation Of Transcription By RNA Polymerase II
Phagocytosis
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Primitive Erythrocyte Differentiation
Ventral Spinal Cord Interneuron Differentiation
Cell Differentiation In Hindbrain
Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain
Central Nervous System Neuron Development
Pituitary Gland Development
Response To Lipid
Somatic Stem Cell Population Maintenance
Regulation Of Histone Acetylation
Eosinophil Fate Commitment
Inner Ear Morphogenesis
Positive Regulation Of Mast Cell Degranulation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Cell Fate Commitment
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Macrophage Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Homeostasis Of Number Of Cells Within A Tissue
Positive Regulation Of Phagocytosis
Positive Regulation Of Phagocytosis, Engulfment
Definitive Hemopoiesis
Semicircular Canal Development
Vascular Wound Healing
Negative Regulation Of Fat Cell Proliferation
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Cochlea Development
GABAergic Neuron Differentiation
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Neural Precursor Cell Proliferation
Negative Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Forebrain Neuron Differentiation
Pathways
Signaling by NODAL
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Transcriptional regulation of granulopoiesis
Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
Colorectal cancer
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
Juvenile polyposis syndrome
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Basophil count (
28031487
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Diastolic blood pressure (
30578418
)
Eosinophil counts (
19198610
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Plateletcrit (
32888494
)
Preterm birth (maternal effect) (
28877031
)
Prostate cancer (
31562322
)
Pulse pressure (
28135244
27841878
30578418
)
Systolic blood pressure (
27841878
)
White blood cell count (
21738480
)
White blood cell count (basophil) (
28158719
)
White blood cell count (eosinophil) (
28158719
)
White blood cell types (
21738478
)
Interacting Genes
214 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFIA
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TIAF1
TLE5
TM9SF2
TOB1
TRAP1
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
46 interacting genes:
ADAMTSL4
AKT1
CDK1
CEBPA
CYSRT1
EP300
FBXW7
FHL3
GOLGA2
HDAC3
HDAC5
HHEX
JUN
KAT2A
KRT40
KRTAP10-3
KRTAP10-9
KRTAP11-1
KRTAP13-3
KRTAP21-2
KRTAP3-1
KRTAP6-3
KRTAP7-1
KRTAP8-1
LMO2
MAPK1
MDFI
MSX2
NOTCH2NLA
PML
POU1F1
POU2AF1
PRR20A
PSMA3
RARA
RBPMS
RXRA
SMAD4
SPI1
STAT3
TAL1
TRAF1
TRIM23
ZBTB16
ZBTB32
ZFPM1
Entrez ID
4089
2624
HPRD ID
02995
00673
Ensembl ID
ENSG00000141646
ENSG00000179348
Uniprot IDs
A0A024R274
Q13485
P23769
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
5O9B
Enriched GO Terms of Interacting Partners
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