MARCKS and TOB1

Data Source:
HPRD (in vitro, two hybrid)

		MARCKS	TOB1
Description		myristoylated alanine rich protein kinase C substrate	transducer of ERBB2, 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Plasma Membrane Focal Adhesion Cell Cortex Actin Cytoskeleton Actin Filament Bundle Germinal Vesicle Extracellular Exosome	Nucleus Cytoplasm CCR4-NOT Complex
	Molecular Function	Protein Kinase C Binding Calmodulin Binding Identical Protein Binding Actin Filament Binding	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding
	Biological Process	Actin Filament Organization Central Nervous System Development Actin Filament Bundle Assembly Actin Crosslink Formation	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Acetylcholine regulates insulin secretion
Drugs
Diseases
GWAS		Bipolar disorder (body mass index interaction) ( 24322204) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Household income ( 31844048) Household income (MTAG) ( 31844048) Type 2 diabetes ( 25760438)	Blood protein levels ( 28240269)
Interacting Genes		14 interacting genes: CALM2 CCNE1 CDK1 CDK2 CDK4 CTSB NMT1 PKN1 PRKCA PRKCB PRKCZ RHOU SPP1 TOB1	19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9
Entrez ID		4082	10140
HPRD ID		07519	09273
Ensembl ID		ENSG00000277443	ENSG00000141232
Uniprot IDs		P29966 Q6NVI1	P50616
PDB IDs			2D5R 2Z15 5CI8 5CI9
Enriched GO Terms of Interacting Partners?
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