ARRB1 and PDE4D

Data Source:
BioGRID (two hybrid)

		ARRB1	PDE4D
Description		arrestin beta 1	phosphodiesterase 4D
Image
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane	Nucleus Microtubule Organizing Center Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Apical Plasma Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Estrogen Receptor Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Follicle-stimulating Hormone Receptor Binding V2 Vasopressin Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Ion Channel Binding Protein Phosphorylated Amino Acid Binding Arrestin Family Protein Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Enzyme Binding CAMP Binding Beta-2 Adrenergic Receptor Binding Ion Channel Binding Metal Ion Binding ATPase Binding Scaffold Protein Binding Heterocyclic Compound Binding
	Biological Process	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Protein Transport Protein Ubiquitination Histone Acetylation Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of GTPase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Response To Drug Follicle-stimulating Hormone Signaling Pathway Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Membrane Organization Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Regulation Of Heart Rate CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of Signaling Receptor Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-5 Production Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Heart Contraction T Cell Receptor Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Endothelial Barrier Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Positive Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Relaxation Of Cardiac Muscle
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants	DARPP-32 events G alpha (s) signalling events
Drugs			Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Amygdala volume ( 31530798) Asthma ( 19426955) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Cognitive function ( 28808816) Cortical surface area (MOSTest) ( 32665545) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) Immune response to smallpox vaccine (IL-6) ( 22610502) Intelligence (MTAG) ( 29326435) Mitochondrial DNA levels ( 30326835) Neuroticism ( 17667963) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 30456828) Plasma parathyroid hormone levels ( 30134803) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to antipsychotic treatment ( 23241943) Sleep duration (long sleep) ( 30846698) Sleep-related phenotypes ( 17903308) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		56 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PRKN PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SREBF2 STAM TRHR ZBTB43	28 interacting genes: ABL1 AKAP6 APP ARRB1 ARRB2 COIL CSNK1A1 FBXO7 FYN GOLGA8EP GOLGA8F GRB2 GSK3B HRAS LYN MAGEA6 MAPK1 MDM2 PAFAH1B1 PDE4DIP PIAS4 PIK3R1 PRKACA RACK1 SPTAN1 SRC TRAF1 TRIM23
Entrez ID		408	5144
HPRD ID		00146	02530
Ensembl ID		ENSG00000137486	ENSG00000113448
Uniprot IDs		B7Z1Q3 P49407	A0A140VJR0 Q08499
PDB IDs		2IV8 6PWC 6TKO 6UP7	1E9K 1MKD 1OYN 1PTW 1Q9M 1TB7 1TBB 1XOM 1XON 1XOQ 1XOR 1Y2B 1Y2C 1Y2D 1Y2E 1Y2K 1ZKN 2FM0 2FM5 2PW3 2QYN 3G4G 3G4I 3G4K 3G4L 3G58 3IAD 3IAK 3K4S 3SL3 3SL4 3SL5 3SL6 3SL8 3V9B 4OGB 4W1O 4WCU 5K1I 5K32 5LBO 5TKB 5WH5 5WH6 5WQA 6AKR 6BOJ 6F6U 6F8R 6F8T 6F8U 6F8V 6F8W 6F8X 6FDC 6FDI 6FE7 6FEB 6FET 6FT0 6FTA 6FTW 6FW3 6HWO 6IAG 6IBF 6IM6 6IMB 6IMD 6IMI 6IMO 6IMR 6IMT 6IND 6INK 6INM 6KJZ 6KK0 6NJH 6NJI 6NJJ 6RCW 6ZBA
Enriched GO Terms of Interacting Partners?
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