M6PR and TMPRSS15

Data Source:
BioGRID (affinity chromatography technology)

		M6PR	TMPRSS15
Description		mannose-6-phosphate receptor, cation dependent	transmembrane serine protease 15
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GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Brush Border Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization	Proteolysis Endocytosis
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases			Enterokinase deficiency
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)	Asthma ( 29273806) Bulimia nervosa ( 23568457) Nucleus accumbens volume in trauma-exposed individuals ( 29187748)
Interacting Genes		12 interacting genes: DUSP12 GGA1 GGA2 GGA3 GIMAP5 HSPA12A JUN KTN1 NINJ2 PLIN3 REN SMCO4	1 interacting genes: SPINK1
Entrez ID		4074	5651
HPRD ID		01106	05972
Ensembl ID		ENSG00000003056	ENSG00000154646
Uniprot IDs		F5GX30 P20645	P98073
PDB IDs		1JUQ	4DGJ 6ZOV
Enriched GO Terms of Interacting Partners?
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