ARR3 and RHO

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		ARR3	RHO
Description		arrestin 3	rhodopsin
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Synapse	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Integral Component Of Membrane Golgi-associated Vesicle Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Sperm Midpiece Photoreceptor Disc Membrane Sperm Head Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Binding Opsin Binding Protein Binding Phosphoprotein Binding	G Protein-coupled Receptor Activity 11-cis Retinal Binding Protein Binding G Protein-coupled Photoreceptor Activity Metal Ion Binding
	Biological Process	Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Signal Transduction Visual Perception	Retinoid Metabolic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Visual Perception Phototransduction Phototransduction, Visible Light Absorption Of Visible Light Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Thermotaxis Photoreceptor Cell Maintenance Detection Of Temperature Stimulus Involved In Thermoception Retina Development In Camera-type Eye Cellular Response To Light Stimulus
Pathways			The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs			Halothane N-Acetylmethionine 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine B-nonylglucoside Phosphonothreonine B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Dodecyldimethylamine N-oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Dexfosfoserine
Diseases			Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO) Retinitis pigmentosa (RP) Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)
GWAS			Diisocyanate-induced asthma ( 25918132) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		20 interacting genes: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 DVL2 FSHR GNMT MAP2K7 MARCHF8 OPN1MW OPN4 PLK4 PTAFR RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496	12 interacting genes: ARR3 ARRB2 CD79A DERL1 GNGT1 GRK1 GRK2 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		407	6010
HPRD ID		02358	01584
Ensembl ID		ENSG00000120500	ENSG00000163914
Uniprot IDs		P36575	P08100
PDB IDs		1XEH 2A34	4ZWJ 5DGY 5W0P 6CMO
Enriched GO Terms of Interacting Partners?
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