LMX1B and LDB1

Data Source:
HPRD (two hybrid)

		LMX1B	LDB1
Description		LIM homeobox transcription factor 1 beta	LIM domain binding 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Activating Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coregulator Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity Protein Self-association DNA-binding Transcription Factor Binding
	Biological Process	In Utero Embryonic Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Dorsal/ventral Pattern Formation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Dopaminergic Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Gastrulation With Mouth Forming Second Hair Follicle Development Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Nervous System Development Anterior/posterior Axis Specification Epithelial Structure Maintenance Wnt Signaling Pathway Cerebellar Purkinje Cell Differentiation Cellular Component Assembly Neuron Differentiation Regulation Of Cell Migration Regulation Of Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Population Maintenance Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Mesendoderm Development Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adult body size ( 32376654) Body fat mass ( 28552196) Body mass index ( 28552196 26961502 28892062 25673413 20935630) Body size at age 10 ( 32376654) Breast cancer ( 29059683 31757997) Calcium levels ( 29403010) Childhood body mass index ( 33045005 26604143) Chin dimples ( 27182965) Eyebrow thickness ( 26926045) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 29449654) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (antiglaucoma preparations and miotics) ( 31015401) Monobrow ( 27182965) Multiple system atrophy ( 27629089) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Social communication problems ( 24564958) Trunk fat mass ( 28552196)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Mean reticulocyte volume ( 32888494) Pulse pressure ( 30578418)
Interacting Genes		5 interacting genes: APP CREB5 HOXA1 LDB1 TCF3	32 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IDI2 IRAK3 ISL1 ISL2 LHX1 LHX2 LHX3 LHX4 LHX6 LHX8 LHX9 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP
Entrez ID		4010	8861
HPRD ID		03986	09144
Ensembl ID		ENSG00000136944	ENSG00000198728
Uniprot IDs		B7ZLH2 O60663 Q6ISE0	A0A6E1WJ75 Q86U70
PDB IDs			2XJY 2XJZ 2YPA 6TYD
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?