MYO18A and ARAF

Data Source:
BioGRID (two hybrid)

		MYO18A	ARAF
Description		myosin XVIIIA	A-Raf proto-oncogene, serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Trans-Golgi Network Cell Surface Membrane Myosin Complex Actomyosin Postsynaptic Golgi Apparatus	Cellular_component Mitochondrion Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding ATP Binding ATPase Activity ADP Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Metabolic Process Golgi Organization Cell Migration Actomyosin Structure Organization Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Golgi Vesicle Budding Positive Regulation Of Protein Secretion Golgi Ribbon Formation Asymmetric Golgi Ribbon Formation Positive Regulation Of Opsonization	MAPK Cascade Activation Of MAPKK Activity Cellular Protein Modification Process Protein Phosphorylation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by MRAS-complex mutants
Drugs			ATP
Diseases			Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Night sleep phenotypes ( 27126917) Sitting height ratio ( 25865494) Smoking behaviour (cigarette pack-years) ( 30679032)
Interacting Genes		4 interacting genes: ARAF ATXN1 GRB2 LINC01554	59 interacting genes: AGTRAP AKT1 ASS1 BAD BECN1 BRAF CCND2 CDK4 CDK6 CDKN2B CHD6 COPS3 CPS1 CSNK2B DIDO1 E2F6 EFEMP1 EPHA2 FGFR4 GLIS2 GNA12 HRAS IRAK2 IRF7 KLHL12 KRAS LATS2 MAP2K1 MAP2K2 MAP2K3 MAP2K5 MLH1 MYC MYO18A NELFCD NF2 NRAS NUDT14 PBK PDGFRB PIK3CA PIK3R1 PKM PRPF6 RABGGTB RASSF1 RGS12 RRAS RRAS2 SFN STK11 TEKT4P2 TESK1 TIMM44 TIRAP TP53 TSC1 WNK1 YWHAG
Entrez ID		399687	369
HPRD ID		10106	02405
Ensembl ID		ENSG00000196535	ENSG00000078061
Uniprot IDs		A0A024QZ63 Q92614 Q9NYE8	A0A024R178 P10398 Q96II5
PDB IDs			1WXM 2MSE
Enriched GO Terms of Interacting Partners?
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