LLGL1 and ACD

Data Source:
HPRD (two hybrid)

		LLGL1	ACD
Description		LLGL scribble cell polarity complex component 1	ACD shelterin complex subunit and telomerase recruitment factor
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Cis Cisterna Cytoplasm Cytoskeleton Plasma Membrane Axon Cortical Actin Cytoskeleton Early Endosome Membrane Trans-Golgi Network Membrane	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	GTPase Activator Activity Structural Molecule Activity Protein Binding Protein Kinase Binding Myosin II Binding	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Axonogenesis Regulation Of Notch Signaling Pathway Cortical Actin Cytoskeleton Organization Regulation Of Establishment Or Maintenance Of Cell Polarity Positive Regulation Of GTPase Activity Regulation Of Protein Secretion Establishment Of Spindle Orientation Protein-containing Complex Assembly	Telomere Maintenance Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		LDL cholesterol ( 30275531)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		6 interacting genes: ACD AGTR1 CACNA1A CD46 STX4 USP11	63 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		3996	65057
HPRD ID		02982	12417
Ensembl ID		ENSG00000131899	ENSG00000102977
Uniprot IDs		Q15334	A0A590TQL1 Q96AP0
PDB IDs			2I46 5H65 5I2X 5I2Y 5UN7 5XYF
Enriched GO Terms of Interacting Partners?
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