LGALS9 and CALCOCO2

Data Source:
HPRD (in vitro)

		LGALS9	CALCOCO2
Description		galectin 9	calcium binding and coiled-coil domain 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Collagen-containing Extracellular Matrix	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Galactose Binding Galactoside Binding Enzyme Binding Carbohydrate Binding Disaccharide Binding	Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Natural Killer Cell Tolerance Induction Chemotaxis Inflammatory Response Female Pregnancy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Lipopolysaccharide Regulation Of Interleukin-4 Production Regulation Of Interleukin-5 Production Negative Regulation Of Chemokine Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway P38MAPK Cascade Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Activated T Cell Proliferation Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Maternal Process Involved In Female Pregnancy Positive Regulation Of Activated T Cell Autonomous Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Interferon-gamma Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Monocyte Chemotactic Protein-1 Production Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Dendritic Cell Apoptotic Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation
Pathways		Interleukin-2 family signaling
Drugs		(R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Irritable mood ( 29500382)	Blood protein levels ( 30072576) Chronotype ( 30696823) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		5 interacting genes: DAZAP2 KRTAP6-3 P4HB PDIA3 PDIA6	180 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC120 CCDC185 CCDC33 CCNH CDC7 CELA2B CEP57L1 CHCHD3 CNNM3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 EFHC1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM214B FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FNDC11 FOXD4L3 FXR2 GABARAPL1 GABARAPL2 GATAD2B GCA GEMIN4 GIT2 GLYCTK HDAC4 HDAC7 HLX HNRNPLL HOXB5 HOXB9 IKBKG IL16 IQUB KANSL1 KAT7 KLHL35 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAP1LC3C MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 PLEKHN1 POLI POLR2A PPP1R18 PRKAA2 PRKAB2 PRPF18 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 QARS1 RAB35 RABL6 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SCAND1 SCNM1 SDCBP SETD5 SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STAMBPL1 STK16 TACO1 TBC1D22B TBK1 TBKBP1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TSGA10IP TTC23L UBAC2 USP2 VARS1 VPS72 ZBTB4 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF414 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF648 ZNF688 ZNF696 ZNF774 ZNF80
Entrez ID		3965	10241
HPRD ID		03528	06846
Ensembl ID		ENSG00000168961	ENSG00000136436
Uniprot IDs		A0A024QZ02 A0A024QZ55 O00182	Q13137
PDB IDs		2EAK 2EAL 2YY1 2ZHK 2ZHL 2ZHM 2ZHN 3LSD 3LSE 3NV1 3NV2 3NV3 3NV4 3WLU 3WV6	2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L
Enriched GO Terms of Interacting Partners?
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