LAG3 and ALCAM

Data Source:
HPRD (in vivo)

		LAG3	ALCAM
Description		lymphocyte activating 3	activated leukocyte cell adhesion molecule
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Immunological Synapse Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Axon Dendrite Intrinsic Component Of Plasma Membrane T Cell Receptor Complex Neuronal Cell Body Extracellular Exosome
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Interleukin-2 Production Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Adaptive Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Motor Neuron Axon Guidance Retinal Ganglion Cell Axon Guidance Axon Extension Involved In Axon Guidance Neuron Projection Extension
Pathways		MHC class II antigen presentation	L1CAM interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Adult body size ( 32376654) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Breast cancer ( 31757997) Chronotype ( 30696823) Cortical surface area (visual PC2) ( 32198502) Erectile dysfunction in type 1 diabetes ( 22704111) Glomerular filtration rate in chronic kidney disease ( 26420894) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Initial pursuit acceleration ( 29064472) Intraocular pressure ( 29617998) Irritable mood ( 29500382) Metabolite levels ( 23823483) Ovarian disease with few adhesions ( 28333195) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Visceral fat ( 30942860)
Interacting Genes		2 interacting genes: CEBPZ CENPJ	3 interacting genes: ART3 CD6 EGFR
Entrez ID		3902	214
HPRD ID		01077	03389
Ensembl ID		ENSG00000089692	ENSG00000170017
Uniprot IDs		P18627	B3KNN9 Q13740
PDB IDs			1KJC 5A2F
Enriched GO Terms of Interacting Partners?
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