RND3 and GCH1

Data Source:
BioGRID (affinity chromatography technology)

		RND3	GCH1
Description		Rho family GTPase 3	GTP cyclohydrolase 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	GTPase Activity GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Translation Initiation Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Negative Regulation Of Blood Pressure Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Protein-containing Complex Assembly Regulation Of Removal Of Superoxide Radicals
Pathways			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs		Guanosine-5'-Triphosphate	Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963)
Interacting Genes		8 interacting genes: ARHGAP5 C14orf119 CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		390	2643
HPRD ID		04233	02573
Ensembl ID		ENSG00000115963	ENSG00000131979
Uniprot IDs		B2R838 P61587	A0A024R642 P30793 Q8IZH9
PDB IDs		1M7B 2V55 4BG6	1FB1
Enriched GO Terms of Interacting Partners?
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