KTN1 and INPP5E

Data Source:
BioGRID (proximity labelling technology)

		KTN1	INPP5E
Description		kinectin 1	inositol polyphosphate-5-phosphatase E
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Ruffle Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cilium Axoneme Golgi Cisterna Membrane
	Molecular Function	RNA Binding Protein Binding Kinesin Binding Cadherin Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
	Biological Process	Microtubule-based Movement Protein Transport Post-translational Protein Modification Cellular Protein Metabolic Process	Phosphatidylinositol Biosynthetic Process Biological_process Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Translation Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Protein Localization To Cilium
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation	Synthesis of PIPs at the Golgi membrane ARL13B-mediated ciliary trafficking of INPP5E
Drugs
Diseases			Joubert syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)	Crohn's disease ( 28067908) Granulocyte count ( 27863252) Hemoglobin A1c levels ( 29403010) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Red cell distribution width ( 32888494) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908 21297633) White blood cell count ( 32888494 27863252)
Interacting Genes		29 interacting genes: ABI1 BNIP3 CD3G CD68 CDC42 CLEC4C CLEC7A EEF1D FFAR2 IKBKE KIF5B KIR2DL3 LHFPL5 M6PR MEOX2 MFSD14B PDCD1LG2 PLEKHA5 RAC1 RHOA RHOG SGTA SIRPA STOM SUSD3 SYNE4 SYNPR TMEM179B UBE2I	1 interacting genes: YWHAG
Entrez ID		3895	56623
HPRD ID		02661	17151
Ensembl ID		ENSG00000126777	ENSG00000148384
Uniprot IDs		A0A024R663 Q86UP2	Q9NRR6
PDB IDs			2XSW
Enriched GO Terms of Interacting Partners?
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