KRT32 and GATAD2A

Data Source:
BioGRID (two hybrid)

		KRT32	GATAD2A
Description		keratin 32	GATA zinc finger domain containing 2A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Extracellular Exosome	Nucleus Nucleoplasm NuRD Complex Nuclear Speck
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Zinc Ion Binding Protein-macromolecule Adaptor Activity Sequence-specific DNA Binding
	Biological Process	Epidermis Development Keratinization Cornification	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Negative Regulation Of Transcription, DNA-templated
Pathways		Keratinization Formation of the cornified envelope	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Height ( 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Nonalcoholic fatty liver disease ( 29385134) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30578418) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Strenuous sports or other exercises ( 29899525) Type 2 diabetes ( 28869590)
Interacting Genes		9 interacting genes: CCDC187 GATAD2A KIFC3 KRT72 KRT80 KRT86 NEDD9 TCHP UBASH3A	15 interacting genes: CBFA2T3 CREBBP H2AC20 H2BC21 H3C1 H4C1 KAT2B KRT32 KRT34 KRT40 MBD2 MBD3 MBD3L1 PAK4 SPOP
Entrez ID		3882	54815
HPRD ID		04134	11741
Ensembl ID		ENSG00000108759	ENSG00000167491
Uniprot IDs		Q14532	A0A024R7K7 A0A024R7M6 Q86YP4
PDB IDs			2L2L
Enriched GO Terms of Interacting Partners?
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