KRTAP10-1 and ECE1

Data Source:
BioGRID (two hybrid)

		KRTAP10-1	ECE1
Description		keratin associated protein 10-1	endothelin converting enzyme 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function		Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Peptide Hormone Binding Protein Homodimerization Activity
	Biological Process	Keratinization	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development
Pathways		Keratinization	Peptide ligand-binding receptors
Drugs			5-(2-hydroxyethyl)nonane-1,9-diol
Diseases
GWAS			Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		138 interacting genes: ADAMTSL4 AEN AMMECR1 ATP23 AVPI1 BAHD1 BCL6B C17orf50 C22orf39 CAMK1G CARD9 CATSPER1 CBX2 CHIC2 CHRD CLPP CRCT1 CREB5 CTSZ CXCL16 CYSRT1 DAAM2 DEFB112 DHX57 DKK1 DOCK2 ECE1 FAM76B FBXO34 FCHO1 FUCA2 GLRX3 HOXA1 HOXA9 HPCAL1 HSD3B7 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP12-1 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP26-1 KRTAP3-2 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP5-1 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LINGO1 MAPKBP1 MEOX2 MOBP MRPL12 NBPF19 NECTIN2 NKD1 NLK NOTCH2NLA NPDC1 NR1D2 NR4A1 NR4A3 NUFIP2 OTX1 PID1 PIN1 PLLP POM121L8P POU4F2 PPARA PRKAG1 PRM2 PRPF31 RNF8 RSPO2 SH3GLB2 SHFL SLC23A1 SLC6A20 SMCP SPATA24 SPATA3 SPATA8 SPRY1 SPRY2 TNP2 TRIM42 TSPAN4 TULP3 WT1 ZBTB24 ZNF101 ZNF124 ZNF138 ZNF264 ZNF286A ZNF329 ZNF417 ZNF433 ZNF438 ZNF439 ZNF440 ZNF559 ZNF572 ZNF581 ZNF587 ZNF625 ZNF664 ZNF768 ZNF785 ZSCAN12 ZSCAN26	14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC
Entrez ID		386677	1889
HPRD ID		11184	02690
Ensembl ID		ENSG00000215455	ENSG00000117298
Uniprot IDs		P60331	A0A024RAB0 A0A024RAB2 A1PUP8 P42892
PDB IDs			3DWB
Enriched GO Terms of Interacting Partners?
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