ARG1 and ALDH4A1

Data Source:
BioGRID (two hybrid)

		ARG1	ALDH4A1
Description		arginase 1	aldehyde dehydrogenase 4 family member A1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrial Outer Membrane Cytosol Azurophil Granule Lumen Specific Granule Lumen Neuron Projection Neuronal Cell Body	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Arginase Activity Protein Binding Manganese Ion Binding Identical Protein Binding	1-pyrroline-5-carboxylate Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Identical Protein Binding
	Biological Process	Urea Cycle Liver Development Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Arginine Catabolic Process Aging Response To Herbicide Response To Manganese Ion Response To Zinc Ion Response To Selenium Ion Regulation Of L-arginine Import Response To Amine Arginine Catabolic Process To Ornithine Lung Development Collagen Biosynthetic Process Response To Vitamin A Response To Vitamin E Negative Regulation Of T Cell Proliferation Response To Drug Defense Response To Protozoan Response To Amino Acid Neutrophil Degranulation Innate Immune Response Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Response To Axon Injury Response To Methylmercury Mammary Gland Involution Maternal Process Involved In Female Pregnancy Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Neutrophil Mediated Killing Of Fungus Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Glucagon Stimulus Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of T-helper 2 Cell Cytokine Production	Proline Metabolic Process Proline Catabolic Process Proline Catabolic Process To Glutamate 4-hydroxyproline Catabolic Process Electron Transport Chain Glyoxylate Metabolic Process
Pathways		Neutrophil degranulation Urea cycle	Glyoxylate metabolism and glycine degradation Proline catabolism
Drugs		Ornithine 2(S)-Amino-6-Boronohexanoic Acid nor-NOHA Dinor-N(Omega)-Hydroxy-L-Arginine S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine S-2-(Boronoethyl)-L-Cysteine Urea Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine S,S-(2-Hydroxyethyl)Thiocysteine DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID S-propylamine-L-cysteine Manganese	NADH
Diseases		Hyperargininemia	Hyperprolinemia (HP)
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) C-reactive protein levels ( 24763700) Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) HDL cholesterol levels ( 32203549) Obesity ( 21552555) Type 2 diabetes ( 30054458)	Alzheimer's disease (survival time) ( 25649651) Anorexia nervosa ( 23568457) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: ALDH4A1 ARG2 CDC42 FLOT1 NOS1 UCHL5	2 interacting genes: APP ARG1
Entrez ID		383	8659
HPRD ID		01947	06009
Ensembl ID		ENSG00000118520	ENSG00000159423
Uniprot IDs		P05089	A0A024RAC7 P30038
PDB IDs		1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE 3THH 3THJ 4FCI 4FCK 4GSM 4GSV 4GSZ 4GWC 4GWD 4HWW 4HXQ 4IE1 6Q92 6Q9P 6QAF 6V7C 6V7D 6V7E 6V7F	3V9G 3V9H 3V9I 4OE5
Enriched GO Terms of Interacting Partners?
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