KLK2 and JADE2

Data Source:
BioGRID (proximity labelling technology)

		KLK2	JADE2
Description		kallikrein related peptidase 2	jade family PHD finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Secretory Granule Extracellular Exosome	Histone Acetyltransferase Complex Nucleoplasm Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity	Protein Binding Transferase Activity Metal Ion Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation	Protein Ubiquitination Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation
Pathways		Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	HATs acetylate histones
Drugs
Diseases
GWAS		Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)	Adult body size ( 32376654) Age at first birth ( 27798627) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hand grip strength ( 29691431) Household income (MTAG) ( 31844048) Mental health study participation (completed survey) ( 31263887) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet distribution width ( 27863252) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 28869590) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2	16 interacting genes: CBX8 CDCA7L CSNK2A1 FBXO7 GAS2L2 GORASP2 H3-4 ING4 ING5 MEAF6 PACSIN1 SASH1 ZBTB3 ZBTB5 ZNF417 ZNF496
Entrez ID		3817	23338
HPRD ID		01006	15124
Ensembl ID		ENSG00000167751	ENSG00000043143
Uniprot IDs		A0A024R4J4 A0A024R4N3 B4DU77 P20151	A0A0C4DFT8 B3KPL2 B4DFY8 G3XAA4 Q9NQC1
PDB IDs		4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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