SLC27A1 and RPE65

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SLC27A1	RPE65
Description		solute carrier family 27 member 1	retinoid isomerohydrolase RPE65
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane	Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cell Body
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Protein Binding Biotin Transmembrane Transporter Activity Fatty Acid Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Oleoyl-CoA Ligase Activity	Phosphatidylserine Binding Retinal Isomerase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Isomerase Activity Phosphatidylcholine Binding Metal Ion Binding Retinol Isomerase Activity All-trans-retinyl-palmitate Hydrolase, 11-cis Retinol Forming Activity All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Cardiolipin Binding
	Biological Process	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Phosphatidylethanolamine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Phosphatidylcholine Biosynthetic Process Phosphatidylserine Biosynthetic Process Phosphatidylinositol Biosynthetic Process Response To Cold Positive Regulation Of Triglyceride Biosynthetic Process Biotin Transport Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Lipid Metabolic Process Positive Regulation Of Heat Generation Cardiolipin Biosynthetic Process Response To Insulin Adiponectin-activated Signaling Pathway Glucose Import In Response To Insulin Stimulus Long-chain Fatty Acid Import Into Cell Negative Regulation Of Phospholipid Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Export Across Plasma Membrane Transport Across Blood-brain Barrier Biotin Import Across Plasma Membrane Lipid Transport Across Blood-brain Barrier	Retinoid Metabolic Process Retina Homeostasis Neural Retina Development Vitamin A Metabolic Process Visual Perception Circadian Rhythm Insulin Receptor Signaling Pathway Regulation Of Gene Expression Retinol Metabolic Process Retinal Metabolic Process Detection Of Light Stimulus Involved In Visual Perception Retina Morphogenesis In Camera-type Eye Cellular Response To Electrical Stimulus Zeaxanthin Biosynthetic Process
Pathways		PPARA activates gene expression Transport of fatty acids	The canonical retinoid cycle in rods (twilight vision)
Drugs			Voretigene neparvovec
Diseases			Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Response to antidepressants ( 20360315)	Facial morphology ( 31763980) Mortality in sepsis ( 27639821) Vertical cup-disc ratio ( 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		1 interacting genes: RPE65	2 interacting genes: RBP4 SLC27A1
Entrez ID		376497	6121
HPRD ID		11863	01569
Ensembl ID		ENSG00000130304	ENSG00000116745
Uniprot IDs		Q6PCB7	Q16518
PDB IDs
Enriched GO Terms of Interacting Partners?
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