KCNJ1 and SGK1

Data Source:
HPRD (in vitro)

		KCNJ1	SGK1
Description		potassium inwardly rectifying channel subfamily J member 1	serum/glucocorticoid regulated kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Inward Rectifier Potassium Channel Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding ATP-activated Inward Rectifier Potassium Channel Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Potassium Ion Transport Excretion Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Cellular Response To Aldosterone
Pathways		Potassium transport channels	Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		Bethanidine Glimepiride Minoxidil Acetohexamide Tolbutamide Glymidine Yohimbine Agmatine Butamben	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases		Bartter syndrome
GWAS			Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		6 interacting genes: GOLGA3 PRKCD SGK1 SH3RF1 SLC9A3R1 SLC9A3R2	37 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C UBC
Entrez ID		3758	6446
HPRD ID		08981	04264
Ensembl ID		ENSG00000151704	ENSG00000118515
Uniprot IDs		A0A024R3K6 A8K432 P48048	B7Z325 E9PR89 O00141
PDB IDs			2R5T 3HDM 3HDN
Enriched GO Terms of Interacting Partners?
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