KCNE1 and CBR3

Data Source:
BioGRID (affinity chromatography technology)

		KCNE1	CBR3
Description		potassium voltage-gated channel subfamily E regulatory subunit 1	carbonyl reductase 3
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GO Annotations	Cellular Component	Lysosome Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Apical Plasma Membrane Z Disc Membrane Raft	Extracellular Space Nucleoplasm Cytosol
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Telethonin Binding Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization	3-keto Sterol Reductase Activity Carbonyl Reductase (NADPH) Activity Protein Binding NADPH Binding
	Biological Process	Sensory Perception Of Sound Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Protein Targeting To Membrane Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Xenobiotic Metabolic Process Phylloquinone Catabolic Process Cognition
Pathways		Phase 3 - rapid repolarisation Phase 2 - plateau phase	Phase I - Functionalization of compounds
Drugs		Enflurane Promethazine Miconazole Azimilide
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732 20062063) Hippocampal volume ( 29274321) L-selectin levels ( 25576479) Long QT syndrome ( 32429735) QT interval ( 30679814 29213071 24952745 31217584)	Blood protein levels ( 30072576 29875488) Lumbar spine bone mineral density ( 22504420)
Interacting Genes		6 interacting genes: ADRB2 KCNH2 KCNQ1 PRKCA TPM3 UBASH3A	5 interacting genes: ARIH2 BICD2 RAB35 SDCBP UBC
Entrez ID		3753	874
HPRD ID		01442	07222
Ensembl ID		ENSG00000180509	ENSG00000159231
Uniprot IDs		A7LFK2 A7LFK4 C7S316 P15382 Q6FHJ6	O75828 V9HW40
PDB IDs		2K21	2HRB
Enriched GO Terms of Interacting Partners?
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