KCND2 and KCNIP4

Data Source:
HPRD (in vivo)

		KCND2	KCNIP4
Description		potassium voltage-gated channel subfamily D member 2	potassium voltage-gated channel interacting protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Postsynaptic Density Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuronal Cell Body Membrane Dendritic Spine Perikaryon Plasma Membrane Raft Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Voltage-gated Potassium Channel Activity A-type (transient Outward) Potassium Channel Activity Protein Binding Metal Ion Binding Voltage-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity
	Biological Process	Action Potential Chemical Synaptic Transmission Neuronal Action Potential Sensory Perception Of Pain Regulation Of Ion Transmembrane Transport Locomotor Rhythm Protein Homooligomerization Regulation Of Postsynaptic Membrane Potential Cardiac Conduction Cellular Response To Hypoxia Potassium Ion Transmembrane Transport	Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels Phase 1 - inactivation of fast Na+ channels	Phase 1 - inactivation of fast Na+ channels
Drugs		Enflurane Disopyramide Imipramine Promethazine Miconazole Dalfampridine
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Alcohol and nicotine co-dependence ( 22488850) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Maximum stenosis ( 32469969) Mean degree of stenosis ( 32469969)	Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)
Interacting Genes		8 interacting genes: DLG4 DPP10 FLNC IL16 KCNIP1 KCNIP2 KCNIP4 NCS1	11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH
Entrez ID		3751	80333
HPRD ID		09254	12184
Ensembl ID		ENSG00000184408	ENSG00000185774
Uniprot IDs		A4D0V9 Q9NZV8	A8K4N3 Q6PIL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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