KCNB1 and KCNE5

Data Source:
BioGRID (fluorescent resonance energy transfer)

		KCNB1	KCNE5
Description		potassium voltage-gated channel subfamily B member 1	potassium voltage-gated channel subfamily E regulatory subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lateral Plasma Membrane Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Sarcolemma Perikaryon Postsynaptic Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ion Channel Binding Protein Heterodimerization Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Action Potential Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Regulation Of Ion Transmembrane Transport Glucose Homeostasis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Regulation Of Motor Neuron Apoptotic Process	Regulation Of Heart Contraction Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Atrial Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cation Channel Activity
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs		Enflurane Promethazine Miconazole Dalfampridine	Enflurane Promethazine Miconazole
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)
Interacting Genes		18 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A VAPA VAPB	7 interacting genes: APP GET3 KCNB1 KCNG4 PGRMC1 SGTA SGTB
Entrez ID		3745	23630
HPRD ID		08983	02268
Ensembl ID		ENSG00000158445	ENSG00000176076
Uniprot IDs		Q14721	Q9UJ90
PDB IDs
Enriched GO Terms of Interacting Partners?
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