ITPR3 and ITPR1

Data Source:
HPRD (in vivo)

		ITPR3	ITPR1
Description		inositol 1,4,5-trisphosphate receptor type 3	inositol 1,4,5-trisphosphate receptor type 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Sarcoplasmic Reticulum Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Nuclear Inner Membrane Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Calcineurin Complex Postsynaptic Density Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Platelet Dense Granule Membrane Platelet Dense Tubular Network Platelet Dense Tubular Network Membrane Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse
	Molecular Function	Inositol Hexakisphosphate Binding Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium-release Channel Activity Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Calcium Ion Binding Protein Binding Calcium Ion Transmembrane Transporter Activity Calcium-release Channel Activity Calcium Channel Inhibitor Activity Phosphatidylinositol Binding Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Memory Platelet Activation Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Regulation Of Cardiac Conduction	Response To Hypoxia Calcium Ion Transport Signal Transduction Post-embryonic Development Regulation Of Autophagy Platelet Activation Endoplasmic Reticulum Calcium Ion Homeostasis Epithelial Fluid Transport Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Negative Regulation Of Calcium-mediated Signaling Voluntary Musculoskeletal Movement Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways		PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	PLC beta mediated events Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Ca2+ pathway cGMP effects Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Caffeine	Caffeine 1D-myo-inositol 1,4,5-trisphosphate Glycerin
Diseases		Type I diabetes mellitus	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma and attention deficit hyperactivity disorder ( 31619474) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 23850713) Educational attainment ( 23722424) Hodgkin's lymphoma ( 30194254) Multiple sclerosis and body mass index (pleiotropy) ( 26920376) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539) Regular attendance at a gym or sports club ( 29970889) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Airflow obstruction ( 22837378) Breast cancer ( 23535729) Calcium levels ( 29403010) Diabetic kidney disease ( 26305897) Gamma glutamyl transferase levels ( 29403010) Hand grip strength ( 29691431) Hematocrit ( 32888494) Lead levels ( 26025379) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Obesity-related traits ( 23251661) Systolic blood pressure ( 26969751) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels ( 32203549 32154731) Uterine fibroids ( 30194396) Weight ( 28552196) Western dietary pattern ( 28644415)
Interacting Genes		19 interacting genes: AKT1 ANK1 BAP1 BECN1 CABP1 FBXL2 ITPR1 MTDH MTNR1A MTNR1B SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	32 interacting genes: AHCYL1 AKT1 ARHGAP1 BANK1 BCL2 BECN1 BRCA1 CA8 CABP1 CCNB1 CDK1 EPB41L1 ERBB2 ERP44 FKBP1A FYN GRM1 HOMER1 HOMER2 HOMER3 IRAG1 ITPR3 ITPRIP LYN PRKACA PRKCD PRKG1 RHOA RYR2 STARD13 TRPC3 TRPC4
Entrez ID		3710	3708
HPRD ID		00926	00925
Ensembl ID		ENSG00000096433	ENSG00000150995
Uniprot IDs		A6H8K3 Q14573 Q59ES2	A0A3B3ITU8 A0A3F2YNW8 B4DER3 B4DGH1 Q14643 Q59H91
PDB IDs		6DQJ 6DQN 6DQS 6DQV 6DQZ 6DR0 6DR2 6DRA 6DRC 6UQK
Enriched GO Terms of Interacting Partners?
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