ITGA2 and TSC22D2

Data Source:
BioGRID (two hybrid)

		ITGA2	TSC22D2
Description		integrin subunit alpha 2	TSC22 domain family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Integrin Alpha2-beta1 Complex Axon Terminus Basal Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Virus Receptor Activity Integrin Binding Protein Binding Collagen Binding Collagen Receptor Activity Laminin Binding Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Migration Substrate-dependent Cell Migration Hypotonic Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Blood Coagulation Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Response To Amine Response To Muscle Activity Positive Regulation Of Smooth Muscle Cell Migration Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of Cell Projection Organization Cell-substrate Adhesion Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Collagen Binding Response To L-ascorbic Acid Cell Adhesion Mediated By Integrin Collagen-activated Signaling Pathway Response To Drug Positive Regulation Of DNA Binding Skin Morphogenesis Establishment Of Protein Localization Positive Regulation Of Translation Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Contraction Viral Entry Into Host Cell Focal Adhesion Assembly Mesodermal Cell Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Positive Chemotaxis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Phagocytosis, Engulfment Hepatocyte Differentiation Response To Parathyroid Hormone Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans CHL1 interactions Platelet Adhesion to exposed collagen MET activates PTK2 signaling
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Type 2 diabetes ( 30130595)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701)
Interacting Genes		13 interacting genes: ACTA1 APP AUP1 CD9 COL1A1 COL1A2 COL8A1 HSPG2 ITGB1 LAMA1 MMP1 RABIF TSC22D2	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		3673	9819
HPRD ID		01893	11101
Ensembl ID		ENSG00000164171	ENSG00000196428
Uniprot IDs		P17301	B4DN36 O75157
PDB IDs		1AOX 1DZI 1PQB 1V7P 4BJ3 5HJ2 5THP 6ND8 6ND9 6NDA 6NDB 6NDC 6NDD 6NDE 6NDF 6NDG 6NDH
Enriched GO Terms of Interacting Partners?
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