ITGA1 and ITGB1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		ITGA1	ITGB1
Description		integrin subunit alpha 1	integrin subunit beta 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Exosome	Ruffle Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Lamellipodium Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Sarcolemma Melanosome Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Glial Cell Projection
	Molecular Function	Signaling Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion	Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding
	Biological Process	Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation Neuron Projection Morphogenesis	Establishment Of Mitotic Spindle Orientation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Cell Migration Cytokine-mediated Signaling Pathway CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Viral Entry Into Host Cell Mesodermal Cell Differentiation Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Wound Healing Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Anoikis
Pathways		Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Other semaphorin interactions Smooth Muscle Contraction CHL1 interactions Platelet Adhesion to exposed collagen	Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events Potential therapeutics for SARS
Drugs			Antithymocyte immunoglobulin (rabbit) MK-0668
Diseases
GWAS		Acne (severe) ( 24927181) Alzheimer's disease biomarkers ( 23419831) Apolipoprotein B levels ( 32203549) Attention deficit hyperactivity disorder ( 28809852) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 26708285) FEV1 ( 30804560) Gamma glutamyl transferase levels ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1/FVC) ( 28166213 30804560) Metabolite levels ( 23823483) Myocardial infarction ( 26708285) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30224653 30578418) Red blood cell count ( 32888494) Response to platinum-based agents ( 22020760) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum thyroid-stimulating hormone levels ( 25436638) Serum total protein level ( 29403010) Total cholesterol levels ( 30275531) Type 2 diabetes ( 30297969 30130595 32499647 30718926 29926116)	Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)
Interacting Genes		10 interacting genes: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1	76 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 UPF2 VCAM1 VCAN YWHAB
Entrez ID		3672	3688
HPRD ID		01892	00628
Ensembl ID		ENSG00000213949	ENSG00000150093
Uniprot IDs		P56199	P05556
PDB IDs		1PT6 1QC5 1QCY 2L8S 2M32 4A0Q 5HGJ	1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4
Enriched GO Terms of Interacting Partners?
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