ISL1 and ZNF511

Data Source:
BioGRID (two hybrid, two hybrid)

		ISL1	ZNF511
Description		ISL LIM homeobox 1	zinc finger protein 511
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Nuclear Receptor Binding Estrogen Receptor Binding BHLH Transcription Factor Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Regulation Of Transcription By RNA Polymerase II Axonogenesis Heart Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Epithelial To Mesenchymal Transition Spinal Cord Motor Neuron Cell Fate Specification Spinal Cord Motor Neuron Differentiation Visceral Motor Neuron Differentiation Trigeminal Nerve Development Pituitary Gland Development Pancreas Development Axon Regeneration Retinal Ganglion Cell Axon Guidance Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Insulin Secretion Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Histone Acetylation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Mesenchymal Cell Differentiation Sensory System Development Peripheral Nervous System Neuron Axonogenesis Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Ventricular Cardiac Muscle Tissue Morphogenesis Pharyngeal System Development Cardiac Muscle Cell Myoblast Differentiation Innervation Atrial Septum Morphogenesis Cardiac Cell Fate Determination Sinoatrial Node Cell Development Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Granulocyte Colony-stimulating Factor Production Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Macrophage Colony-stimulating Factor Production	Regulation Of Transcription By RNA Polymerase II
Pathways		Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol use disorder (consumption score) ( 30940813) Automobile speeding propensity ( 30643258) Brain morphology (MOSTest) ( 32665545) Childhood body mass index ( 33045005) Childhood ear infection ( 27182965) Classic bladder exstrophy ( 25763902) Cortical surface area (MOSTest) ( 32665545) Dental caries ( 23259602) Diastolic blood pressure ( 27841878) Emotional lability in attention deficit hyperactivity disorder ( 31085060) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Verbal declarative memory ( 25648963) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Nonunion in individuals with fractures ( 30680360)
Interacting Genes		21 interacting genes: APP CDK6 CDKN2B CRK ESR1 HNF4A ISL2 KDM1A LDB1 LDB2 LHX1 LHX3 LMO2 LMX1A NR2F1 PECR PLCG2 RELA RLIM SMAD3 ZNF511	15 interacting genes: BOLA2 BOLA2B CFAP206 CLCNKA ENKD1 HSF2BP ISL1 KAT5 LHX2 LMO1 MAD2L2 NTAQ1 SCNM1 SMARCD1 TMCO6
Entrez ID		3670	118472
HPRD ID		02650	15812
Ensembl ID		ENSG00000016082	ENSG00000198546
Uniprot IDs		P61371	Q8NB15
PDB IDs
Enriched GO Terms of Interacting Partners?
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