IRF6 and CENPF

Data Source:
BioGRID (biochemical)

		IRF6	CENPF
Description		interferon regulatory factor 6	centromere protein F
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Complex Binding
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation Cranial Skeletal System Development	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Muscle Organ Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
GWAS		Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360) Serum immune biomarker levels ( 32066700)
Interacting Genes		4 interacting genes: IRF8 RFX3 TLX2 ZBTB3	10 interacting genes: BRAP CENPE CHMP2B FNTA FNTB NDEL1 NUP133 SNAP25 SVIL TOP3B
Entrez ID		3664	1063
HPRD ID		06227	02582
Ensembl ID		ENSG00000117595	ENSG00000117724
Uniprot IDs		G0Z349 O14896	P49454
PDB IDs
Enriched GO Terms of Interacting Partners?
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