CENPF and NUP133

Data Source:
HPRD (two hybrid, in vivo)

		CENPF	NUP133
Description		centromere protein F	nucleoporin 133
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromatin Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Axoneme Nuclear Matrix Midbody Ciliary Basal Body Pronucleus Perinuclear Region Of Cytoplasm Ciliary Transition Fiber	Condensed Chromosome Kinetochore Condensed Chromosome Outer Kinetochore Nuclear Envelope Nuclear Pore Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Host Cell
	Molecular Function	Chromatin Binding Protein Binding Microtubule Binding Protein C-terminus Binding Transcription Factor Binding Protein Homodimerization Activity Dynein Complex Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Mitotic Cell Cycle Kidney Development Chromosome Segregation Mitotic Spindle Assembly Checkpoint Muscle Organ Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Regulation Of Striated Muscle Tissue Development Ventricular System Development Cell Differentiation Response To Drug Negative Regulation Of Transcription, DNA-templated Cell Division Metaphase Plate Congression Kinetochore Assembly Regulation Of Cell Cycle DNA Biosynthetic Process	Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Nuclear Pore Organization Viral Process Protein Sumoylation Poly(A)+ MRNA Export From Nucleus Viral Transcription Neural Tube Development Neurogenesis Paraxial Mesoderm Development Regulation Of Gene Silencing By MiRNA Somite Development Nephron Development Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Lung function (FVC) ( 30061609) Response to antineoplastic agents ( 21659360) Serum immune biomarker levels ( 32066700)	Type 2 diabetes ( 32499647)
Interacting Genes		10 interacting genes: BRAP CENPE CHMP2B FNTA FNTB NDEL1 NUP133 SNAP25 SVIL TOP3B	4 interacting genes: CENPF NUP107 NUP98 TCAP
Entrez ID		1063	55746
HPRD ID		02582	06354
Ensembl ID		ENSG00000117724	ENSG00000069248
Uniprot IDs		P49454	Q8WUM0
PDB IDs			1XKS 3CQC 3CQG 3I4R 5A9Q
Enriched GO Terms of Interacting Partners?
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