IREB2 and FBXL5

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IREB2	FBXL5
Description		iron responsive element binding protein 2	F-box and leucine rich repeat protein 5
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Ubiquitin Ligase Complex Cytosol SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Aconitate Hydratase Activity Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Ubiquitin-protein Transferase Activity Iron Ion Binding Protein Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Post-embryonic Development Negative Regulation Of Translation Osteoclast Differentiation Erythrocyte Homeostasis Intestinal Absorption Iron Ion Homeostasis	Protein Polyubiquitination Cellular Iron Ion Homeostasis Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Iron Ion Homeostasis Positive Regulation Of Cellular Protein Catabolic Process
Pathways		Iron uptake and transport	Association of TriC/CCT with target proteins during biosynthesis Neddylation Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Chronic obstructive pulmonary disease ( 25241909 22080838 20173748) Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774) Diffusing capacity of carbon monoxide ( 30694715) Emotional recognition ( 31596458) Emphysema distribution in smoking ( 27669027) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary artery enlargement in chronic obstructive pulmonary disease ( 25101718) Schizophrenia ( 25056061 29483656)	Blood protein levels ( 28240269) Estimated glomerular filtration rate in non-diabetics ( 31451708) Red blood cell count ( 32888494)
Interacting Genes		6 interacting genes: APP FBXL5 RBCK1 TERT USP53 YBX1	11 interacting genes: CITED2 CSNK2B DCTN1 EP300 IREB2 LINC00839 NABP2 ORC4 PLK1 SKP1 SNCA
Entrez ID		3658	26234
HPRD ID		08858	05739
Ensembl ID		ENSG00000136381	ENSG00000118564
Uniprot IDs		D3DW85 P48200	Q9UKA1
PDB IDs		6VCD	3U9J 3U9M 3V5X 3V5Y 3V5Z 6VCD
Enriched GO Terms of Interacting Partners?
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