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IL12RB2 and IL12B
Data Source:
HPRD
(in vivo)
IL12RB2
IL12B
Description
interleukin 12 receptor subunit beta 2
interleukin 12B
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Receptor Complex
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Cytosol
External Side Of Plasma Membrane
Late Endosome Lumen
Receptor Complex
Interleukin-12 Complex
Interleukin-23 Complex
Molecular Function
Cytokine Receptor Activity
Cytokine Binding
Cytokine Receptor Activity
Cytokine Activity
Interleukin-12 Receptor Binding
Protein Binding
Growth Factor Activity
Cytokine Binding
Interleukin-12 Alpha Subunit Binding
Identical Protein Binding
Protein-containing Complex Binding
Interleukin-23 Receptor Binding
Protein Heterodimerization Activity
Biological Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-gamma Production
Interleukin-12-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
Natural Killer Cell Activation Involved In Immune Response
Positive Regulation Of T-helper 1 Type Immune Response
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Cell Cycle Arrest
Cell Population Proliferation
Response To UV-B
Positive Regulation Of Activation Of Janus Kinase Activity
Cell Migration
Cytokine-mediated Signaling Pathway
Sensory Perception Of Pain
Sexual Reproduction
Natural Killer Cell Activation
Interferon-gamma Production
Negative Regulation Of Interleukin-10 Production
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Natural Killer Cell Activation
Positive Regulation Of Natural Killer Cell Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Tissue Remodeling
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
T-helper 1 Type Immune Response
T-helper Cell Differentiation
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Activated T Cell Proliferation
Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Defense Response To Protozoan
Positive Regulation Of Memory T Cell Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Cell Adhesion
Negative Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Negative Regulation Of Protein Secretion
Positive Regulation Of Inflammatory Response
Defense Response To Gram-negative Bacterium
Positive Regulation Of NK T Cell Activation
Positive Regulation Of NK T Cell Proliferation
Defense Response To Virus
Cellular Response To Lipopolysaccharide
Cellular Response To Interferon-gamma
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways
Interleukin-35 Signalling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Drugs
5-Mercapto-2-Nitro-Benzoic Acid
Briakinumab
Ustekinumab
Ustekinumab
humanized SMART Anti-IL-12 Antibody
Tapinarof
Tildrakizumab
Risankizumab
Diseases
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Behcet's disease (
20622878
20622879
)
Blood protein levels (
30072576
29875488
)
Crohn's disease (
28067908
22412388
)
Crohn's disease or systemic sclerosis (
32024964
)
Inflammatory bowel disease (
28067908
23128233
)
Medication use (thyroid preparations) (
31015401
)
Primary biliary cholangitis (
19458352
21399635
20639880
26394269
)
Rheumatoid arthritis (
32868391
)
Severe malaria (
29381699
)
Severe malaria (adjusted for sickle cell variant rs334) (
29381699
)
Systemic lupus erythematosus (
33536424
26502338
28714469
19838195
)
Systemic sclerosis (
31672989
29293537
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Type 2 diabetes (age of onset) (
28060188
)
Ulcerative colitis (
28067908
)
Ankylosing spondylitis (
23749187
21743469
)
Blood protein levels (
30072576
29875488
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
30500874
28067908
17554261
20570966
21102463
32581322
)
Cutaneous psoriasis (
26626624
)
Inflammatory bowel disease (
28067908
26278503
23128233
)
interleukin 12 receptor subunit beta-1 levels (
25147954
)
Leprosy (
32421744
25642632
)
Multiple sclerosis (
22190364
21833088
)
Pediatric autoimmune diseases (
26301688
)
Primary biliary cholangitis (
26394269
)
Psoriasis (
25854761
25903422
20953188
20953190
23143594
19169254
19169255
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
20953186
)
Response to taxane treatment (placlitaxel) (
23006423
)
Sarcoidosis (
26051272
)
Serum sulfate level (
27412988
)
Takayasu arteritis (
23830517
)
Ulcerative colitis (
28067908
21297633
)
Interacting Genes
5 interacting genes:
IL12B
IL12RB1
JAK2
SOCS3
STAT4
3 interacting genes:
IL12A
IL12RB1
IL12RB2
Entrez ID
3595
3593
HPRD ID
03383
01194
Ensembl ID
ENSG00000081985
ENSG00000113302
Uniprot IDs
A0A0A0MTN7
B4DGA4
B7ZB60
Q99665
P29460
PDB IDs
1F42
1F45
3D85
3D87
3DUH
3HMX
3QWR
4GRW
5MJ3
5MJ4
5MXA
5MZV
5NJD
6UIB
Enriched GO Terms of Interacting Partners
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