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IL12RB1 and BRD4
Data Source:
BioGRID
(biochemical)
IL12RB1
BRD4
Description
interleukin 12 receptor subunit beta 1
bromodomain containing 4
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Interleukin-12 Receptor Complex
Receptor Complex
Interleukin-23 Receptor Complex
Condensed Nuclear Chromosome
Nucleus
Nucleoplasm
Molecular Function
Cytokine Receptor Activity
Interleukin-12 Receptor Binding
Interleukin-12 Receptor Activity
Cytokine Binding
Interleukin-23 Binding
Interleukin-23 Receptor Activity
P53 Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Enzyme Binding
Lysine-acetylated Histone Binding
RNA Polymerase II C-terminal Domain Binding
P-TEFb Complex Binding
Biological Process
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of T-helper 1 Type Immune Response
Signal Transduction
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interferon-gamma Production
Interleukin-12-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Memory T Cell Differentiation
Cellular Response To Interferon-gamma
Positive Regulation Of T-helper 17 Type Immune Response
Positive Regulation Of T-helper 17 Cell Lineage Commitment
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Chromatin Organization
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain
Positive Regulation Of Histone H3-K36 Trimethylation
Pathways
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Potential therapeutics for SARS
Drugs
Diseases
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Blood protein levels (
28240269
)
Mental health study participation (completed survey) (
31263887
)
Pulmonary function in asthmatics (
23541324
)
Systemic sclerosis (
31672989
30572963
)
Immature fraction of reticulocytes (
32888494
)
Mean reticulocyte volume (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Systolic blood pressure (
30578418
)
Interacting Genes
6 interacting genes:
IL12B
IL12RB2
IL23A
IL23R
SNRPD3
STAT4
17 interacting genes:
C7orf25
C8orf33
CCNT1
CCNT2
CHFR
CLDN1
COPS5
H3C14
H4-16
H4C14
MESD
PRPF40A
RFC1
RFC4
TRIM55
TRIM63
USP17L2
Entrez ID
3594
23476
HPRD ID
03363
10574
Ensembl ID
ENSG00000096996
ENSG00000141867
Uniprot IDs
P42701
A0A024R7H8
O60885
PDB IDs
2I8N
2LSP
2MJV
2N3K
2NCZ
2ND0
2ND1
2NNU
2OSS
2OUO
2YEL
2YEM
3MXF
3P5O
3SVF
3SVG
3U5J
3U5K
3U5L
3UVW
3UVX
3UVY
3UW9
3ZYU
4A9L
4BJX
4BW1
4BW2
4BW3
4BW4
4C66
4C67
4CFK
4CFL
4CL9
4CLB
4DON
4E96
4F3I
4GPJ
4HBV
4HBW
4HBX
4HBY
4HXK
4HXL
4HXM
4HXN
4HXO
4HXP
4HXR
4HXS
4IOO
4IOQ
4IOR
4J0R
4J0S
4J3I
4KV1
4KV4
4LR6
4LRG
4LYI
4LYS
4LYW
4LZR
4LZS
4MEN
4MEO
4MEP
4MEQ
4MR3
4MR4
4NQM
4NR8
4NUC
4NUD
4NUE
4O70
4O71
4O72
4O74
4O75
4O76
4O77
4O78
4O7A
4O7B
4O7C
4O7E
4O7F
4OGI
4OGJ
4PCE
4PCI
4PS5
4QB3
4QR3
4QR4
4QR5
4QZS
4UIX
4UIY
4UIZ
4UYD
4WHW
4WIV
4X2I
4XY9
4XYA
4YH3
4YH4
4Z1Q
4Z1S
4Z93
4ZC9
4ZW1
5A5S
5A85
5ACY
5AD2
5AD3
5BT4
5CFW
5COI
5CP5
5CPE
5CQT
5CRM
5CRZ
5CS8
5CTL
5CY9
5D0C
5D24
5D25
5D26
5D3H
5D3J
5D3L
5D3N
5D3P
5D3R
5D3S
5D3T
5DLX
5DLZ
5DW2
5DX4
5E0R
5EGU
5EI4
5EIS
5F5Z
5F60
5F61
5F62
5F63
5FBX
5H21
5HCL
5HLS
5HM0
5HQ5
5HQ6
5HQ7
5I80
5I88
5IGK
5JWM
5KDH
5KHM
5KJ0
5KU3
5LJ1
5LJ2
5LRQ
5LUU
5M39
5M3A
5MKZ
5MLI
5N2M
5NNC
5NND
5NNE
5NNF
5NNG
5O97
5OVB
5OWM
5OWW
5T35
5TI2
5TI3
5TI4
5TI5
5TI6
5TI7
5U28
5U2C
5U2E
5U2F
5UEO
5UEP
5UEQ
5UER
5UES
5UET
5UEU
5UEV
5UEX
5UEY
5UEZ
5UF0
5ULA
5UOO
5UVS
5UVT
5UVU
5UVV
5UVW
5UVX
5UVY
5UVZ
5V67
5VBO
5VBP
5VOM
5VZS
5W55
5WA5
5WMA
5WMD
5WMG
5WUU
5XHY
5XI2
5XI3
5XI4
5Y1Y
5Y8C
5Y8W
5Y8Y
5Y8Z
5Y93
5Y94
5YOU
5YOV
5YQX
5Z1R
5Z1S
5Z1T
5Z5T
5Z5U
5Z5V
5Z8G
5Z8R
5Z8Z
5Z90
5Z9C
5Z9K
6AFR
6AJV
6AJW
6AJX
6AJY
6AJZ
6BN7
6BN8
6BN9
6BNB
6BNH
6BOY
6C7Q
6C7R
6CD4
6CD5
6CIS
6CIY
6CJ1
6CJ2
6CKR
6CKS
6CZU
6CZV
6DJC
6DL2
6DMJ
6DML
6DNE
6DUV
6E4A
6FFD
6FNX
6FO5
6FSY
6FT3
6FT4
6G0D
6G0E
6G0F
6G0G
6G0H
6G0O
6G0P
6G0Q
6G0R
6G0S
6HDQ
6HOV
6I7X
6I7Y
6IN1
6JI3
6JI4
6JI5
6JJ3
6JJ5
6JJ6
6JJB
6KEC
6KED
6KEE
6KEF
6KEG
6KEH
6KEI
6KEJ
6KEK
6KO2
6MAU
6MH1
6MH7
6MNL
6P05
6PRT
6PS9
6PSB
6Q3Y
6Q3Z
6S25
6SE4
6SIS
6SWN
6SWQ
6TPX
6TPY
6TPZ
6U0D
6U6K
6U6L
6U72
6U74
6U8G
6U8I
6U8M
6ULS
6UVJ
6UVM
6UWU
6UWX
6V0U
6V1K
6V1L
6V1U
6VIW
6VIX
6VIZ
6VUB
6VUC
6VUF
6VUJ
6WGX
6WW8
6X7B
6X7C
6X7D
6XUZ
6XV3
6XV7
6XVC
6YIN
6YQN
6YQO
6YQP
6Z7G
6Z7L
6Z7M
6ZB3
6ZED
6ZEL
6ZF9
7A9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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