IL12RB1 and IL23R

Data Source:
HPRD (in vitro, in vivo)

		IL12RB1	IL23R
Description		interleukin 12 receptor subunit beta 1	interleukin 23 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Plasma Membrane External Side Of Plasma Membrane Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Cellular Response To Interferon-gamma Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Inflammatory Response Positive Regulation Of Activation Of Janus Kinase Activity Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Response To Interferon-gamma Interleukin-23-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Osteoclast Differentiation Defense Response To Gram-negative Bacterium Positive Regulation Of NK T Cell Activation Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-4 and Interleukin-13 signaling Interleukin-23 signaling Interleukin-23 signaling
Drugs
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	Crohn's disease
GWAS		Blood protein levels ( 28240269) Mental health study participation (completed survey) ( 31263887) Pulmonary function in asthmatics ( 23541324) Systemic sclerosis ( 31672989 30572963)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187 21743469 20062062) Behcet's disease ( 20622878 20622879) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 30500874 28067908 20570966 22936669 22412388 17435756 17554300 21102463 17447842 22293688 32581322 23850713 17804789) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28008999 18758464 28067908 23128233) Inflammatory skin disease ( 25574825) Leprosy ( 25642632 22019778) Pediatric autoimmune diseases ( 26301688) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Psoriasis ( 25903422 20953190 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Sarcoidosis ( 26051272) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699) Type 2 diabetes (age of onset) ( 28060188) Ulcerative colitis ( 19915572 28067908 26398853 20228799 21297633 19122664 32072174) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		6 interacting genes: IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	5 interacting genes: C1D IL12RB1 IL23A JAK2 STAT3
Entrez ID		3594	149233
HPRD ID		03363	16249
Ensembl ID		ENSG00000096996	ENSG00000162594
Uniprot IDs		P42701	Q5VWK5
PDB IDs			5MZV
Enriched GO Terms of Interacting Partners?
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