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IL7R and HNRNPU
Data Source:
BioGRID
(unspecified method)
IL7R
HNRNPU
Description
interleukin 7 receptor
heterogeneous nuclear ribonucleoprotein U
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Clathrin-coated Vesicle Membrane
Nuclear Chromosome
Kinetochore
Condensed Chromosome Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Telomerase Holoenzyme Complex
Centrosome
Cell Surface
Membrane
Nuclear Matrix
Nuclear Speck
Midbody
Dendrite Cytoplasm
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Catalytic Step 2 Spliceosome
Mitotic Spindle
RNA Polymerase II Transcription Regulator Complex
Inactive Sex Chromosome
Mitotic Spindle Midzone
Mitotic Spindle Microtubule
Ribonucleoprotein Complex
Molecular Function
Antigen Binding
Cytokine Receptor Activity
Interleukin-7 Receptor Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
TFIIH-class Transcription Factor Complex Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA 3'-UTR Binding
Actin Binding
Protein Binding
ATP Binding
Poly(A) Binding
SnRNA Binding
Poly(C) RNA Binding
Chromatin DNA Binding
Poly(G) Binding
Pre-mRNA Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Telomerase RNA Binding
RNA Polymerase II C-terminal Domain Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Regulation Of DNA Recombination
Cell Morphogenesis
Negative Regulation Of T Cell Mediated Cytotoxicity
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Size
Positive Regulation Of Gene Expression
T Cell Differentiation
Positive Regulation Of T Cell Differentiation In Thymus
Interleukin-7-mediated Signaling Pathway
B Cell Proliferation
Lymph Node Development
Homeostasis Of Number Of Cells
Defense Response To Gram-positive Bacterium
Membrane Organization
Negative Regulation Of T Cell Apoptotic Process
Positive Regulation Of Receptor Signaling Pathway Via STAT
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
Chromatin Organization
RNA Processing
Cell Cycle
Regulation Of Mitotic Cell Cycle
Dosage Compensation By Inactivation Of X Chromosome
Viral Process
RNA Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Circadian Regulation Of Gene Expression
Negative Regulation Of Kinase Activity
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Stabilization
Cell Division
Maintenance Of Protein Location In Nucleus
Cardiac Muscle Cell Development
CRD-mediated MRNA Stabilization
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Brown Fat Cell Differentiation
Dendritic Transport Of Messenger Ribonucleoprotein Complex
Regulation Of Mitotic Spindle Assembly
Regulation Of Chromatin Organization
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Protein Localization To Spindle Microtubule
RNA Localization To Chromatin
Cellular Response To Leukemia Inhibitory Factor
Adaptive Thermogenesis
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Stem Cell Differentiation
Pathways
Interleukin-7 signaling
Interleukin-7 signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
30013184
31361310
)
Ankylosing spondylitis (
23749187
)
Asthma (
31361310
30929738
32296059
31619474
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
26482879
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
29875488
28240269
)
Eczema (
31361310
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
21244703
24076602
19525953
21833088
)
Neutrophil percentage of white cells (
32888494
27863252
)
Primary biliary cholangitis (
23000144
21399635
26394269
28062665
30643196
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
33536424
)
Type 1 diabetes (
25751624
17554260
)
Ulcerative colitis (
21297633
)
White blood cell count (
32888494
)
Interacting Genes
110 interacting genes:
AGTRAP
ALYREF
APOL3
CIRBP
CPSF1
CRLF2
DDX21
DDX39B
DDX3X
DDX5
DHX36
DHX9
EIF2AK2
ELAVL1
EMG1
FAU
FUS
FYN
G3BP1
H1-10
H1-2
H1-4
H2BC21
HNRNPA0
HNRNPA3
HNRNPAB
HNRNPC
HNRNPD
HNRNPDL
HNRNPH3
HNRNPL
HNRNPR
HNRNPU
HNRNPUL1
HNRNPUL2
IL2RG
IL7
ILF2
ILF3
JAK1
JAK3
KIT
LYN
MALL
MAP4
MS4A1
NCL
NONO
PABPC1
PABPC4
PABPN1
PIK3R1
PTBP1
PTK2B
PTMA
PURA
PURB
QKI
RACK1
RAD21
RBM3
RBMX
RPL15
RPL18
RPL22
RPL29
RPL30
RPL31
RPL6
RPL7
RPL8
RPS20
RPS3
RPSA
RRAGA
RSL1D1
SAFB
SDC4
SF1
SF3A1
SF3B1
SNRNP70
SNRPA
SNRPB
SNRPD1
SNRPD2
SNRPD3
SNRPE
SNRPF
SNRPG
SRP14
SRP9
SRSF3
SRSF9
SSB
STAT3
STAT5A
STAT5B
SYNCRIP
TMEM120B
TOE1
TOP1
TSLP
U2AF1
U2AF2
YBX1
YBX3
YWHAE
YWHAG
ZNF787
38 interacting genes:
ACTB
BTRC
CASP3
CD5
CDKN2A
CR2
DUX4
ELL
EP300
ERG
GRIN1
GRIN2D
GTF2H1
HNRNPH3
HSPB1
IL7R
KAT2B
NDN
NDRG1
NEDD4
NR3C1
PIN1
POLR2A
POU3F4
PRMT1
PRPF40A
PTPN11
RBPMS2
SMN1
SREK1
STAU1
SUMO2
SYK
TCERG1
UBE2I
WBP4
YAP1
ZNF689
Entrez ID
3575
3192
HPRD ID
00893
04185
Ensembl ID
ENSG00000168685
ENSG00000153187
Uniprot IDs
P16871
Q00839
Q96BA7
PDB IDs
3DI2
3DI3
3UP1
5J11
6P50
6P67
1ZRJ
Enriched GO Terms of Interacting Partners
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