IL3 and BRD8

Data Source:
BioGRID (affinity chromatography technology)

		IL3	BRD8
Description		interleukin 3	bromodomain containing 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Swr1 Complex Nucleoplasm Mitochondrion NuA4 Histone Acetyltransferase Complex
	Molecular Function	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity	Protein Binding Nuclear Receptor Coactivator Activity Thyroid Hormone Receptor Binding
	Biological Process	MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation	Cell Surface Receptor Signaling Pathway Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling	HATs acetylate histones
Drugs		Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Menarche (age at onset) ( 25231870)
Interacting Genes		5 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD	12 interacting genes: AGTR1 EP400 FSD2 MCRS1 MIS18A MRGBP PIN1 PPARG RXRA THRB TRRAP WEE1
Entrez ID		3562	10902
HPRD ID		00987	04166
Ensembl ID		ENSG00000164399	ENSG00000112983
Uniprot IDs		P08700	B4DEG9 B4DMS9 B4DN43 Q9H0E9
PDB IDs		1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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