IL2 and IL2RA

Data Source:
HPRD (in vivo)

		IL2	IL2RA
Description		interleukin 2	interleukin 2 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	MAPK Cascade Negative Regulation Of Protein Phosphorylation Adaptive Immune Response Leukocyte Activation Involved In Immune Response Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Immune Response Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Cytokine-mediated Signaling Pathway Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Kinase Activity Positive Regulation Of Tissue Remodeling Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Response To Ethanol Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Heart Contraction Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of T-helper 17 Cell Differentiation	MAPK Cascade Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cytokine-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response
Pathways		RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide keyhole limpet hemocyanin Girentuximab Tapinarof TG4010	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases		Graft-versus-host disease Type I diabetes mellitus	Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 20596022 25608926) Asthma ( 31361310 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 26482879 23727859) Bipolar disorder ( 31043756) Celiac disease ( 22057235 20190752 25920553 17558408 24999842 18311140) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (adrenergics, inhalants) ( 31015401) Primary sclerosing cholangitis ( 23603763 27992413) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342 20453842) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 19525953 19525955 17660530 21833088 27386562 28445677) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24449572 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480 30572963 22293688 18978792) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494)
Interacting Genes		8 interacting genes: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR SHC1	8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		3558	3559
HPRD ID		00979	00986
Ensembl ID		ENSG00000109471	ENSG00000134460
Uniprot IDs		P60568 Q0GK43	P01589 Q5W005
PDB IDs		1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU
Enriched GO Terms of Interacting Partners?
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